Nanoplastics (NPs) are widespread in ecosystems and their biohazards are of accelerating concern. The hazards of NPs to aquatic and terrestrial crops and aquatic animals have been extensively studied, whereas the hazards to mammals are nonetheless being explored. Right here, we carried out a meta-analysis to quantify the final depth of NPs results on mice and developed two machine studying strategies to foretell the correlates of the detrimental results of NPs. We discovered that NPs have a variety of poisonous results on varied techniques, and their antagonistic results had been primarily associated to toxicity metrics, adopted by the scale, kind, and mass focus of NPs, in addition to publicity routes, publicity time, and mouse gender. These outcomes recommend that the toxicity of NPs to mammals is dependent upon various responses starting from the molecular to the bioindividual scale, that are influenced by the properties of the NPs themselves and by environmental circumstances that complicate their toxicity and have a variety of results.