Bone infections are a fancy scientific problem, usually brought on by bacterial infections, main to break and dysfunction of bone tissue. Conventional remedies primarily depend on antibiotics (ABs); nevertheless, they’ve limitations equivalent to low permeability and the event of resistance. In current occasions, the progress in tissue engineering has launched novel approaches to sort out bone infections. Biocompatible scaffolds not solely function supportive buildings for bone defects but additionally perform as drug supply techniques, enabling focused launch of antimicrobial medication to reinforce anti-inflammatory and antibacterial results. The drug launch price from drug-loaded scaffolds might be managed, which helps to handle infections whereas selling bone therapeutic and enhancing the synergistic results of antibacterial motion and bone restore. This evaluate discusses the newest developments in scaffold supplies for the discharge of antimicrobial medication, analyzes the present challenges in analysis, and descriptions future instructions for growth, offering a foundation for scientific functions.