Melanoma is an aggressive type of pores and skin most cancers with a excessive mortality charge as soon as it metastasizes. Localized chemotherapy is usually an choice solely within the early phases (in situ melanoma) or as a postoperative therapy following surgical removing of suspicious lesions. Medicine resembling Imiquimod, 5-Fluorouracil, Dacarbazine, and Doxorubicin have been examined for this function, exhibiting promising results. Extra lately, researchers have been exploring the potential of steel nanoparticles, each as standalone remedies and as drug carriers.
Silver nanoparticles (AgNPs) have gained explicit consideration in nanomedicine, drug supply, and theranostics on account of their broad antimicrobial and anti-tumor properties. Their pharmacological results, nevertheless, are intently tied to their “floor performance.”
Research recommend that negatively charged, spherical AgNPs are typically much less poisonous than their positively charged or irregularly formed counterparts (resembling rods or wires). Nevertheless, this diminished toxicity additionally means they are usually much less efficient as anti-cancer brokers.
Fashionable pharmaceutical growth more and more emphasizes eco-friendly, or “inexperienced,” applied sciences that eradicate the necessity for poisonous solvents and reagents. This examine utilized one such method, using Camellia sinensis (inexperienced tea leaves) as a pure decreasing agent for silver ions.
To boost each antimicrobial and anti-tumor exercise, the AgNPs have been additional conjugated with chlorhexidine (Cx+), a broad-spectrum antimicrobial agent and cationic surfactant. The outcomes have been putting: the AgNP-Cx+ complexes demonstrated considerably stronger antimicrobial properties, an 18-fold improve in anti-melanoma exercise, and thrice larger tumor selectivity in comparison with non-functionalized AgNPs.
Maybe probably the most important end result of this analysis, lately printed in Pharmacia, was the event of an adhesive patch prototype for topical utility of the AgNP-Cx+ advanced. The chosen polymers—Hydroxypropyl methylcellulose and Eudragit® RS—didn’t intervene with the antiproliferative motion of the lively agent. The truth is, they helped double its exercise whereas enhancing tumor selectivity even additional.
Journal Reference:
Ivanova, N. A., et. al. (2025) Anti-melanoma exercise of green-produced nanosilver-chlorhexidine advanced. Pharmacia. doi.org/10.3897/pharmacia.72.e143419
