18.4 C
Canberra
Monday, February 23, 2026

Extremely-rapid nanoplasmonic colorimetry in microfluidics for antimicrobial susceptibility testing instantly from specimens


  • Murray, C. J. et al. International burden of bacterial antimicrobial resistance in 2019: a scientific evaluation. Lancet 399, 629–655 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Essack, S. Y. & Lenglet, A. Bacterial antimicrobial resistance burden in Africa: accuracy, motion, and options. Lancet Glob. Heal. 12, e171–e172 (2023).

    Article 

    Google Scholar
     

  • McKay, G. & Nguyen, D. in Handbook of Antimicrobial Resistance (eds Berghuis, A. et al.) 203–229 (Springer, 2017).

  • Solà-Riera, C., Gupta, S., Ljunggren, H.-G. & Klingström, J. Orthohantaviruses belonging to 3 phylogroups all inhibit apoptosis in contaminated goal cells. Sci. Rep. 9, 834 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Břinda, Ok. et al. Fast inference of antibiotic resistance and susceptibility by genomic neighbour typing. Nat. Microbiol. 5, 455–464 (2020).

  • Wiegand, I., Hilpert, Ok. & Hancock, R. E. W. Agar and broth dilution strategies to find out the minimal inhibitory focus (MIC) of antimicrobial substances. Nat. Protoc. 3, 163–175 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vodstrcil, L. A. et al. Close to-to-patient-testing to tell focused antibiotic use for sexually transmitted infections in a public sexual well being clinic: the NEPTUNE cohort research. Lancet Reg. Well being West. Pac. 44, 101005 (2024).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cheng, M. P. et al. Blood tradition outcomes earlier than and after antimicrobial administration in sufferers with extreme manifestations of sepsis: a diagnostic research. Ann. Intern. Med. 171, 547–554 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Sartorius, B. et al. The burden of bacterial antimicrobial resistance within the WHO African area in 2019: a cross-country systematic evaluation. Lancet Glob. Well being 11, 201–216 (2023).

  • VITEK 2 AST–Gram Detrimental Ciprofloxacin (≤0.06–≥4 µg/mL) Normal No. K214023 (bioMérieux Inc., 2022); https://www.accessdata.fda.gov/cdrh_docs/critiques/K214023.pdf

  • MicroScan Dried Gram Detrimental MIC/Combo Panels with Ciprofloxacin (Cp) (0.004–8 µg/mL) Normal No. K193536 (Beckman Coulter Inc., 2020); https://www.accessdata.fda.gov/cdrh_docs/critiques/K193536.pdf

  • BD Phoenix Automated Microbiology System—GN Ceftaroline (0.0156–4 µg/mL) Normal No. K190905 (Becton Dickinson and Firm, 2019); https://www.accessdata.fda.gov/cdrh_docs/critiques/K190905.pdf

  • Baltekin, Ö, Boucharin, A., Tano, E., Andersson, D. I. & Elf, J. Antibiotic susceptibility testing in lower than 30 min utilizing direct single-cell imaging. Proc. Natl Acad. Sci. USA 114, 9170–9175 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kaushik, A. M. et al. Droplet-based single-cell measurements of 16S rRNA allow built-in micro organism identification and pheno-molecular antimicrobial susceptibility testing from medical samples in 30 min. Adv. Sci. 8, 2003419 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Kim, T. H. et al. Blood culture-free ultra-rapid antimicrobial susceptibility testing. Nature 632, 893–902 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kearns, H., Goodacre, R., Jamieson, L. E., Graham, D. & Faulds, Ok. SERS detection of a number of antimicrobial-resistant pathogens utilizing nanosensors. Anal. Chem. 89, 12666–12673 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zeeshan, Bahrami, S., Park, S. & Cho, S. Antibody functionalized capacitance sensor for label-free and real-time detection of micro organism and antibiotic susceptibility. Talanta 272, 125831 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Music, J. H. et al. Vertical capacitance aptasensors for real-time monitoring of bacterial development and antibiotic susceptibility in blood. Biosens. Bioelectron. 143, 111623 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Reszetnik, G. et al. Subsequent-generation speedy phenotypic antimicrobial susceptibility testing. Nat. Commun. 15, 9719 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kumar, Ok. et al. Printing color on the optical diffraction restrict. Nat. Nanotechnol. 7, 557–561 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Daqiqeh Rezaei, S. et al. Nanophotonic structural colours. ACS Photonics 8, 18–33 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Bhalla, N. & Shen, A. Q. Localized floor plasmon resonance sensing and its interaction with fluidics. Langmuir 40, 9842–9854 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schirato, A. et al. Quantifying ultrafast vitality switch from plasmonic scorching carriers for pulsed photocatalysis on nanostructures. ACS Nano 18, 18933–18947 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang, L. et al. Massive space plasmonic shade palettes with expanded gamut utilizing colloidal self-assembly. ACS Photonics 3, 627–633 (2016).

    Article 
    CAS 

    Google Scholar
     

  • Rycenga, M. et al. Controlling the synthesis and meeting of silver nanostructures for plasmonic functions. Chem. Rev. 111, 3669–3712 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu, Y., Ng, C., König, T. A. F. & Fery, A. Tackling the scalability problem in plasmonics by wrinkle-assisted colloidal self-assembly. Langmuir 35, 8629–8645 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li, Y., Chen, X. & Gu, N. Computational investigation of interplay between nanoparticles and membranes: hydrophobic/hydrophilic impact. J. Phys. Chem. B 112, 16647–16653 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Alafeef, M., Moitra, P., Dighe, Ok. & Pan, D. RNA-extraction-free nano-amplified colorimetric check for point-of-care medical prognosis of COVID-19. Nat. Protoc. 16, 3141–3162 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Santopolo, G., Doménech-Sánchez, A., Russell, S. M. & de la Rica, R. Ultrafast and ultrasensitive naked-eye detection of urease-positive micro organism with plasmonic nanosensors. ACS Sens. 4, 961–967 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Duan, H., Wang, T., Su, Z., Pang, H. & Chen, C. Current progress and challenges in plasmonic nanomaterials. Chem. Rev. 122, 846–873 (2022).

  • Choi, S., Zuo, J., Das, N., Yao, Y. & Wang, C. Scalable nanoimprint manufacturing of purposeful multilayer metasurface units. Adv. Funct. Mater. 34, 2404852 (2024).

    Article 
    CAS 

    Google Scholar
     

  • Gu, Y., Zhang, L., Yang, J. Ok. W., Yeo, S. P. & Qiu, C. W. Shade era through subwavelength plasmonic nanostructures. Nanoscale 7, 6409–6419 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lim, Ok. T. P., Liu, H., Liu, Y. & Yang, J. Ok. W. Holographic color prints for enhanced optical safety by mixed section and amplitude management. Nat. Commun. 10, 25 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Daqiqeh Rezaei, S. et al. Tunable, cost-effective, and scalable structural colours for sensing and shopper merchandise. Adv. Decide. Mater. 7, 1900735 (2019).

    Article 
    CAS 

    Google Scholar
     

  • AbdElFatah, T. et al. Nanoplasmonic amplification in microfluidics allows accelerated colorimetric quantification of nucleic acid biomarkers from pathogens. Nat. Nanotechnol. 18, 922–932 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Riss, T. L. et al. in Assay Steering Handbook 1–25 (Eli Lilly & Firm and the Nationwide Heart for Advancing Translational Sciences, 2004).

  • Braissant, O., Astasov-Frauenhoffer, M., Waltimo, T. & Bonkat, G. A evaluation of strategies to find out viability, vitality, and metabolic charges in microbiology. Entrance. Microbiol. 11, 547458 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Efficiency Requirements for Antimicrobial Susceptibility Testing Normal No. M100, thirty first edn (Medical and Laboratory Requirements Institute, 2021).

  • Uzarski, J. S., DiVito, M. D., Wertheim, J. A. & Miller, W. M. Important design concerns for the resazurin discount assay to noninvasively quantify cell enlargement inside perfused extracellular matrix scaffolds. Biomaterials 129, 163–175 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, J. L., Steele, T. W. J. & Stuckey, D. C. Metabolic discount of resazurin; location inside the cell for cytotoxicity assays. Biotechnol. Bioeng. 115, 351–358 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Flores-Mireles, A. L., Walker, J. N., Caparon, M. & Hultgren, S. J. Urinary tract infections: epidemiology, mechanisms of an infection and therapy choices. Nat. Rev. Microbiol. 13, 269–284 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Primack, W., Bukowski, T., Sutherland, R., Gravens-Mueller, L. & Carpenter, M. What urinary colony rely signifies a urinary tract an infection in youngsters? J. Pediatr. 191, 259–261.e1 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Strategies for Dilution Antimicrobial Susceptibility Checks for Micro organism That Develop Aerobically Normal No. M07, eleventh edn (Medical and Laboratory Requirements Institute, 2018).

  • Hooton, T. M. et al. Analysis, prevention, and therapy of catheter-aassociated urinary tract an infection in adults: 2009 worldwide medical apply pointers from the infectious ailments society of America. Clin. Infect. Dis. 50, 625–663 (2010).

    Article 
    PubMed 

    Google Scholar
     

  • Kalil, A. C. et al. Administration of adults with hospital-acquired and ventilator-associated pneumonia: 2016 Medical Observe Pointers by the Infectious Ailments Society of America and the American Thoracic Society. Clin. Infect. Dis. 63, e61–e111 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rose, W. E. et al. Elevated endovascular Staphylococcus aureus inoculum is the hyperlink between elevated serum interleukin 10 concentrations and mortality in sufferers with bacteremia. Clin. Infect. Dis. 64, 1406–1412 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lopes, A. L. Ok. et al. Growth of a magnetic separation methodology to seize sepsis related micro organism in blood. J. Microbiol. Strategies https://doi.org/10.1016/j.mimet.2016.07.012 (2016).

    Article 
    PubMed 

    Google Scholar
     

  • Yagupsky, P. & Nolte, F. S. Quantitative facets of septicemia. Clin. Microbiol. Rev. https://doi.org/10.1128/CMR.3.3.269 (1990).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mermel, L. A. et al. Quantitative evaluation and molecular fingerprinting of methicillin-resistant Staphylococcus aureus nasal colonization in numerous affected person populations: a potential, multicenter research. Infect. Management Hosp. Epidemiol. 31, 592–597 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • O’Hara, L. M. et al. Optimizing contact precautions to curb the unfold of antibiotic-resistant micro organism in hospitals: a multicenter cohort research to establish affected person traits and healthcare personnel interactions related to transmission of methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. https://doi.org/10.1093/cid/ciz621 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mohammed, M. I. & Desmulliez, M. P. Y. Characterization and theoretical evaluation of quickly prototyped capillary motion autonomous microfluidic techniques. J. Microelectromech. Syst. 23, 1408–1416 (2014).

    Article 
    CAS 

    Google Scholar
     

  • Glière, A. & Delattre, C. Modeling and fabrication of capillary cease valves for planar microfluidic techniques. Sens. Actuators A Phys. 130–131, 601–608 (2006).

    Article 

    Google Scholar
     

  • Olanrewaju, A., Beaugrand, M., Yafia, M. & Juncker, D. Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits. Lab Chip 18, 2323–2347 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Papadimitriou, V. A., Segerink, L. I., van den Berg, A. & Eijkel, J. C. T. 3D capillary cease valves for versatile patterning inside microfluidic chips. Anal. Chim. Acta 1000, 232–238 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jalali, M. et al. Plasmonic nanobowtiefluidic machine for delicate detection of glioma extracellular vesicles by Raman spectrometry. Lab Chip 21, 855–866 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • IInnocenzi, P. et al. Hierarchical mesoporous movies: from self-assembly to porosity with totally different size scales. Chem. Mater. 23, 2501–2509 (2011).

    Article 

    Google Scholar
     

  • Sergyan, S. Shade histogram options primarily based picture classification in content-based picture retrieval techniques. In Proc. sixth Worldwide Symposium on Utilized Machine Intelligence and Informatics 221–224 (IEEE, 2008).

  • Zhou, L., Menon, S. S., Li, X., Zhang, M. & Malakooti, M. H. Machine studying allows dependable colorimetric detection of pH and glucose in wearable sweat sensors. Adv. Mater. Technol. 9, 2401121 (2024).


    Google Scholar
     

  • Pisner, D. A. & Schnyer, D. M. in Machine Studying: Strategies and Purposes to Mind Problems (eds Mechelli, A. & Vieira, S.) 101–121 (Tutorial Press, 2020).

  • Shahriari, B., Swersky, Ok., Wang, Z., Adams, R. P. & Freitas, N. de Taking the human out of the loop: a evaluation of Bayesian optimization. Proc. IEEE 104, 148–175 (2016).

    Article 

    Google Scholar
     

  • Christianson, S. et al. Comparative genomics of Canadian epidemic lineages of methicillin-resistant Staphylococcus aureus. J. Clin. Microbiol. 45, 1904–1911 (2007).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hill, J. et al. Loop-mediated isothermal amplification assay for speedy detection of widespread strains of Escherichia coli. J. Clin. Microbiol. 46, 2800–2804 (2008).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Isenberg, H. in Medical Microbiology Procedures Handbook third edn, Ch. 3.12 (American Society for Microbiology, 2009).

  • McCarter, Y. S. et al. Cumitech 2C: Laboratory Analysis of Urinary Tract Infections (ed. Sharp, S. E.) (American Society for Microbiology, 2009).

  • Zhang, M. et al. Fast dedication of antimicrobial susceptibility by stimulated Raman scattering imaging of D2O metabolic incorporation in a single bacterium. Adv. Sci. 7, 2001452 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Nguyen, A. V. et al. Ladder-shaped microfluidic system for speedy antibiotic susceptibility testing. Commun. Eng. 2, 15 (2023).

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Huang, R. et al. Bioinspired plasmonic nanosensor for on-site antimicrobial susceptibility testing in urine samples. ACS Nano 16, 19229–19239 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ho, C.-S. et al. Fast identification of pathogenic micro organism utilizing Raman spectroscopy and deep studying. Nat. Commun. 10, 4927 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Related Articles

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    [td_block_social_counter facebook="tagdiv" twitter="tagdivofficial" youtube="tagdiv" style="style8 td-social-boxed td-social-font-icons" tdc_css="eyJhbGwiOnsibWFyZ2luLWJvdHRvbSI6IjM4IiwiZGlzcGxheSI6IiJ9LCJwb3J0cmFpdCI6eyJtYXJnaW4tYm90dG9tIjoiMzAiLCJkaXNwbGF5IjoiIn0sInBvcnRyYWl0X21heF93aWR0aCI6MTAxOCwicG9ydHJhaXRfbWluX3dpZHRoIjo3Njh9" custom_title="Stay Connected" block_template_id="td_block_template_8" f_header_font_family="712" f_header_font_transform="uppercase" f_header_font_weight="500" f_header_font_size="17" border_color="#dd3333"]
    - Advertisement -spot_img

    Latest Articles