ABSTRACT: Cuproptosis has not too long ago acquired a lot consideration in most cancers therapy. Nonetheless, copper ionophores donât present the apparent scientific efficacy. Though some Cu-based and copper ionophores-loaded nanomaterials have been utilized to induce cuproptosis, it’s tough to attain the scientific translation restricted by the difficult composition, harsh synthesis situation, exterior stimulus, and potential biotoxicity. Phytic acid, a naturally occurring natural phosphorus carbohydrate, possesses distinct antineoplastic impact on multiply kinds of most cancers and excessive biocompatibility. Based mostly on metal-phosphonate coordination, a novel Cu-phytic acid nanozyme (denoted as CP) with pH/GSH dual-response was fabricated by a âone-spotâ methodology. CP with three enzyme-mimicking actions enhanced cuproptosis remedy by way of GSH depletion, reactive oxygen species increase, hypoxia aid and the attenuation of glycolysis. As a proof of idea, Elesclomol (a copper ionophore)-resistant A549 cells had been used to research CP- induced cuproptosis for inhibition of tumor progress in vitro and in vivo.
