The structural attributes of RNA, particularly co-transcriptional folding, have enabled RNA origami to assemble advanced 3D architectures, serving as a platform to construct RNA-based nanodevices. Nonetheless, the potential of RNA in molecular electronics is basically unexplored, primarily on account of its inherent conformational fluctuations. Though this variability poses challenges for a exact understanding of the conductance properties of RNA, it additionally gives alternatives for tuning RNA-based molecular units by exploiting their dynamic nature. Accordingly, our goals on this paper are twofold: (i) how do conformational fluctuations influence the cost transport properties of single stranded RNA (ssRNA), and (ii) how can these fluctuations be managed? Towards that finish, we first established a benchmark for ssRNA instability in comparison with double stranded RNA (dsRNA) primarily based on molecular dynamics. Subsequently, we discover quantum transport throughout 123 distinct conformations, which present that the typical conductance of ssRNA is 1.7 × 10−3 G0, however with a excessive commonplace deviation of round 5.2 × 10−3 G0. We show that the conductance of ssRNA is influenced primarily by spine bending and nucleotide positioning. Particularly, whereas spine bending tends to lead to greater conductance at lowered end-to-end phosphorus distances, nucleotide positioning introduces vital stochasticity. To mitigate this variability, we additionally show that growing the salt focus can stabilize ssRNA, presenting a viable technique for minimizing conductance fluctuations. Our findings reveal that if ssRNA conductance will be switched between folded and unfolded states, it could supply two distinct conductance modes. We anticipate the programmability of ssRNA folding and sturdiness, coupled with its conductivity, will be leveraged for advancing molecular electronics.
