Nano-catalytic remedy is an rising tumor therapeutic technique that has acquired appreciable consideration in recent times. This strategy can convert endogenous hydrogen peroxide (H2O2) on the tumor website into extremely poisonous hydroxyl radicals (˙OH) through a Fenton or Fenton-like response catalyzed by steel ions. Nevertheless, the low ranges of ˙OH generated merely from endogenous H2O2 are normally inadequate to successfully kill most cancers cells. To deal with this limitation, we developed an environment friendly biomimetic nanozyme (HMPB/LAP@TK-CCM) designed to amplify intracellular oxidative stress and alleviate tumor hypoxia for enhanced nano-catalytic remedy. This nanozyme is loaded with the anticancer drug β-lapachone (LAP), which will increase H2O2 ranges inside the tumor cells, thus enhancing the Fenton response of HMPB. The camouflaging technique utilizing a cancer-thylakoid hybrid membrane reduces the immune clearance of the nanoparticles and promotes their accumulation on the tumor website. The thylakoid membrane (TK) additionally incorporates pure catalase, which alleviates tumor hypoxia by producing oxygen, thus facilitating the technology of H2O2 by LAP and additional enhancing the synergistic anti-tumor impact. Moreover, in vivo research demonstrated that HMPB/LAP@TK-CCM NPs successfully restrain tumor development with out negatively impacting regular tissues.
