20.4 C
Canberra
Thursday, April 24, 2025

Biomaterial-based drug supply techniques within the therapy of internal ear problems | Journal of Nanobiotechnology


  • Mahshid SS, Higazi AM, Ogier JM, Dabdoub A. Extracellular biomarkers of internal ear illness and their potential for point-of-care diagnostics. Adv Sci (Weinh). 2022;9:e2104033.

    Article 
    PubMed 

    Google Scholar
     

  • Chadha S, Kamenov Okay, Cieza A. The world report on listening to, 2021. Bull World Well being Organ. 2021;99:242–A242.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Su YT, Guo YB, Cheng YP, Zhang X, Xie XP, Chang YM, Bao JX. Hyperbaric oxygen therapy ameliorates listening to loss and auditory cortex harm in noise uncovered mice by repressing native ceramide accumulation. Int J Mol Sci. 2019;20.

  • Brock PR, Maibach R, Childs M, Rajput Okay, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall’Igna P, Hiyama E, et al. Sodium thiosulfate for defense from cisplatin-induced listening to loss. N Engl J Med. 2018;378:2376–85.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Y, Fang Q, Wang H, Qi J, Solar S, Liao M, Wu Y, Hu Y, Jiang P, Cheng C, et al. Elevated mitophagy protects cochlear hair cells from aminoglycoside-induced harm. Autophagy. 2023;19:75–91.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tian L, He L, Jackson Okay, Saif A, Khan S, Wan Z, Didar TF, Hosseinidoust Z. Self-assembling nanofibrous bacteriophage microgels as sprayable antimicrobials focusing on multidrug-resistant micro organism. Nat Commun. 2022;13:7158.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tian L, Jackson Okay, He L, Khan S, Thirugnanasampanthar M, Gomez M, Bayat F, Didar TF, Hosseinidoust Z. Excessive-throughput fabrication of antimicrobial phage microgels and instance functions in meals decontamination. Nat Protoc. 2024;19:1591–622.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Korver AM, Smith RJ, Van Camp G, Schleiss MR, Bitner-Glindzicz MA, Lustig LR, Usami SI, Boudewyns AN. Congenital listening to loss. Nat Rev Dis Primers. 2017;3:16094.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nyberg S, Abbott NJ, Shi X, Steyger PS, Dabdoub A. Supply of therapeutics to the internal ear: the problem of the blood-labyrinth barrier. Sci Transl Med. 2019;11.

  • Fritzsch B, Silos-Santiago I, Bianchi LM, Fariñas I. The function of neurotrophic elements in regulating the event of internal ear innervation. Tendencies Neurosci. 1997;20:159–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li L, Luo J, Lin X, Tan J, Li P. Nanomaterials for internal ear illnesses: challenges, limitations and alternatives. Mater (Basel). 2022;15.

  • Zhang H, Chen H, Lu L, Wang H, Zhao Y, Chai R. Pure multifunctional silk microcarriers for noise-induced listening to loss remedy. Adv Sci (Weinh). 2024;11:e2305215.

    Article 
    PubMed 

    Google Scholar
     

  • Takeda H, Dondzillo A, Randall JA, Gubbels SP. Challenges in cell-based therapies for the therapy of listening to loss. Tendencies Neurosci. 2018;41:823–37.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pan X, Li Y, Huang P, Staecker H, He M. Extracellular vesicles for growing focused listening to loss remedy. J Management Launch. 2024;366:460–78.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ma Y, Smart AK, Shepherd RK, Richardson RT. New molecular therapies for the therapy of listening to loss. Pharmacol Ther. 2019;200:190–209.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jiang L, Wang D, He Y, Shu Y. Advances in gene remedy maintain promise for treating hereditary listening to loss. Mol Ther. 2023;31:934–50.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen H, Solar L, Wang Y, Cai L, Zhao Y, Shang L. Biomimetic air purification with liquid-gating topological gradient microfluidics. Nat Chem Eng. 2024;1:650–60.

    Article 

    Google Scholar
     

  • Shan J, Che J, Tune C, Zhao Y. Rising antibacterial nanozymes for wound therapeutic. Sensible Med. 2023;2:e20220025.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tian L, He L, Jackson Okay, Mahabir R, Hosseinidoust Z. Micro organism repellent protein hydrogel embellished with tunable, isotropic, nano-on-micro hierarchical microbump array. Chem Commun (Camb). 2021;57:10883–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang X, Lu M, Cao X, Zhao Y. Purposeful microneedles for wearable electronics. Sensible Med. 2023;2:e20220023.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Swan EE, Mescher MJ, Sewell WF, Tao SL, Borenstein JT. Inside ear drug supply for auditory functions. Adv Drug Deliv Rev. 2008;60:1583–99.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Koushik TM, Miller CM, Antunes E. Bone tissue engineering scaffolds: perform of multi-material hierarchically structured scaffolds. Adv Healthc Mater. 2023;12:e2202766.

    Article 
    PubMed 

    Google Scholar
     

  • Glueckert R, Johnson Chacko L, Rask-Andersen H, Liu W, Handschuh S, Schrott-Fischer A. Anatomical foundation of drug supply to the internal ear. Hear Res. 2018;368:10–27.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li L, Chao T, Brant J, O’Malley B Jr., Tsourkas A, Li D. Advances in nano-based internal ear supply techniques for the therapy of sensorineural listening to loss. Adv Drug Deliv Rev. 2017;108:2–12.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu S, Wang S, Zou L, Xiong W. Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and depth. Cell Mol Life Sci. 2021;78:5083–94.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Driver EC, Kelley MW. Improvement of the cochlea. Improvement. 2020;147.

  • White HJ, Helwany M, Biknevicius AR, Peterson DC. Anatomy, Head and Neck, Ear Organ of Corti. In StatPearls. Treasure Island (FL) ineligible corporations. Disclosure: Muhammad Helwany declares no related monetary relationships with ineligible corporations. Disclosure: Audrone Biknevicius declares no related monetary relationships with ineligible corporations. Disclosure: Diana Peterson declares no related monetary relationships with ineligible corporations.: StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025.

  • Dubrulle F, Chaton V, Risoud M, Farah H, Charley Q, Vincent C. The spherical window signal: a delicate signal to detect perilymphatic fistulae on delayed postcontrast 3D-FLAIR sequence. Eur Radiol. 2020;30:6303–10.

    Article 
    PubMed 

    Google Scholar
     

  • Rathnam C, Chueng SD, Ying YM, Lee KB, Kwan Okay. Developments in bio-inspired nanomaterials for therapeutic supply to deal with listening to loss. Entrance Cell Neurosci. 2019;13:493.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Holley MC. Keynote evaluation: the auditory system, listening to loss and potential targets for drug growth. Drug Discov As we speak. 2005;10:1269–82.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pararas EE, Borkholder DA, Borenstein JT. Microsystems applied sciences for drug supply to the internal ear. Adv Drug Deliv Rev. 2012;64:1650–60.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lynch ED, Kil J. Compounds for the prevention and therapy of noise-induced listening to loss. Drug Discov As we speak. 2005;10:1291–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Borenstein JT. Intracochlear drug supply techniques. Knowledgeable Opin Drug Deliv. 2011;8:1161–74.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sendowski I, Abaamrane L, Raffin F, Cros A, Clarençon D. Therapeutic efficacy of intra-cochlear administration of methylprednisolone after acoustic trauma attributable to gunshot noise in Guinea pigs. Hear Res. 2006;221:119–27.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rybak LP. Mechanisms of cisplatin ototoxicity and progress in otoprotection. Curr Opin Otolaryngol Head Neck Surg. 2007;15:364–9.

    Article 
    PubMed 

    Google Scholar
     

  • Rybak LP, Whitworth CA. Ototoxicity: therapeutic alternatives. Drug Discov As we speak. 2005;10:1313–21.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rybak LP, Ramkumar V. Ototoxicity. Kidney Int. 2007;72:931–5.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res. 2007;226:157–67.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Autoimmune sensorineural listening to loss. Lancet. 1980;1:187.


    Google Scholar
     

  • Matteson EL, Fabry DA, Strome SE, Driscoll CL, Beatty CW, McDonald TJ. Autoimmune internal ear illness: diagnostic and therapeutic approaches in a multidisciplinary setting. J Am Acad Audiol. 2003;14:225–30.

    Article 
    PubMed 

    Google Scholar
     

  • Pathak S, Vambutas A. Autoimmune internal ear illness patient-associated 28-kDa proinflammatory IL-1β fragment outcomes from caspase-7-mediated cleavage in vitro. JCI Perception. 2020;5.

  • Shamriz O, Tal Y, Gross M. Autoimmune internal ear illness: immune biomarkers, audiovestibular facets, and therapeutic modalities of Cogan’s syndrome. J Immunol Res. 2018;2018:1498640.

  • Komune S, Snow JB Jr. Ototoxicity of Kanamycin sulfate and the obstacles within the internal ear. Otolaryngol Head Neck Surg. 1981;89:1013–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen GD, Daszynski DM, Ding D, Jiang H, Woolman T, Blessing Okay, Kador PF, Salvi R. Novel oral multifunctional antioxidant prevents noise-induced listening to loss and hair cell loss. Hear Res. 2020;388:107880.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wilson WR, Byl FM, Laird N. The efficacy of steroids within the therapy of idiopathic sudden listening to loss. A double-blind medical research. Arch Otolaryngol. 1980;106:772–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, et al. Scientific apply guideline: sudden listening to loss (Replace). Otolaryngol Head Neck Surg. 2019;161:S1–45.

    PubMed 

    Google Scholar
     

  • Graham MD, Sataloff RT, Kemink JL. Titration streptomycin remedy for bilateral Meniere’s illness: a preliminary report. Otolaryngol Head Neck Surg. 1984;92:440–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sajjadi H, Paparella MM. Meniere’s illness. Lancet. 2008;372:406–14.

    Article 
    PubMed 

    Google Scholar
     

  • Balyan FR, Taibah A, De Donato G, Aslan A, Falcioni M, Russo A, Sanna M. Titration streptomycin remedy in Meniere’s illness: long-term outcomes. Otolaryngol Head Neck Surg. 1998;118:261–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug supply for therapy of internal ear illness: present state of data. Ear Hear. 2010;31:156–65.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang C, Yu Y, Shang L, Zhao Y. Versatile hemline-shaped microfibers for liquid transport. Nat Chem Eng. 2024;1:87–96.

    Article 

    Google Scholar
     

  • Mirsalehi M, Ghajarzadeh M, Farhadi M, Akbarnejad Z, Ahmadi S, Salem MM. Intratympanic corticosteroid injection as a first-line therapy of the sufferers with idiopathic sudden sensorineural listening to loss in comparison with systemic steroid: a scientific evaluation and meta-analysis. Am J Otolaryngol. 2022;43:103505.

    Article 
    PubMed 

    Google Scholar
     

  • Jackson LE, Silverstein H. Chemical perfusion of the internal ear. Otolaryngol Clin North Am. 2002;35:639–53.

    Article 
    PubMed 

    Google Scholar
     

  • Rauch SD, Halpin CF, Antonelli PJ, Babu S, Carey JP, Gantz BJ, Goebel JA, Hammerschlag PE, Harris JP, Isaacson B, et al. Oral vs intratympanic corticosteroid remedy for idiopathic sudden sensorineural listening to loss: a randomized trial. JAMA. 2011;305:2071–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jung SY, Kim S, Kang Z, Kwon S, Lee J, Park JW, Kim KS, Kim DK. Effectivity of a dexamethasone nanosuspension as an intratympanic injection for acute listening to loss. Drug Deliv. 2022;29:149–60.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang W, Cai L, Gan J, Zhao Y. Photothermal responsive porous hole microneedles as Chinese language medication versatile supply system for wound therapeutic. Sensible Med. 2024;3:e20240007.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Suryanarayanan R, Prepare dinner JA. Lengthy-term outcomes of gentamicin internal ear perfusion in Ménière’s illness. J Laryngol Otol. 2004;118:489–95.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bowe SN, Jacob A. Spherical window perfusion dynamics: implications for intracochlear remedy. Curr Opin Otolaryngol Head Neck Surg. 2010;18:377–85.

    Article 
    PubMed 

    Google Scholar
     

  • Li L, Ren J, Yin T, Liu W. Intratympanic dexamethasone perfusion versus injection for therapy of refractory sudden sensorineural listening to loss. Eur Arch Otorhinolaryngol. 2013;270:861–7.

    Article 
    PubMed 

    Google Scholar
     

  • Hoffer ME, Kopke RD, Weisskopf P, Gottshall Okay, Allen Okay, Wester D. Microdose gentamicin administration by way of the spherical window microcatheter: ends in sufferers with Meniere’s illness. Ann N Y Acad Sci. 2001;942:46–51.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sale PJP, Uschakov A, Saief T, Rowe DP, Abbott CJ, Luu CD, Hampson AJ, O’Leary SJ, Sly DJ. Cannula-based drug supply to the Guinea pig spherical window causes an enduring listening to loss that could be quickly mitigated by BDNF. Hear Res. 2017;356:104–15.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Malfeld Okay, Baumhoff P, Volk HA, Lenarz T, Scheper V. Native long-term internal ear drug supply in regular listening to guinea pig-an animal mannequin to develop preventive therapy for noise-induced listening to loss. Biomolecules. 2022;12.

  • Schwieger J, Frisch AS, Rau TS, Lenarz T, Hügl S, Scheper V. 3D printed cell tradition chamber for testing the impact of pump-based continual drug supply on internal ear tissue. Biomolecules. 2022;12.

  • Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel method to transdermal drug supply. J Pharm Sci. 1999;88:948.

    CAS 
    PubMed 

    Google Scholar
     

  • Leong S, Aksit A, Feng SJ, Kysar JW, Lalwani AK. Inside ear diagnostics and drug supply by way of microneedles. J Clin Med. 2022;11.

  • Aksit A, Rastogi S, Nadal ML, Parker AM, Lalwani AK, West AC, Kysar JW. Drug supply system for the internal ear: ultra-sharp totally metallic microneedles. Drug Deliv Transl Res. 2021;11:214–26.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luo X, Yang L, Cui Y. Microneedles: supplies, fabrication, and biomedical functions. Biomed Microdevices. 2023;25:20.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ahmed S, Al-Japairai Okay, Mahmood S, Hamed Almurisi S, Reddy Venugopal J, Rebhi Hilles A, Azmana M, Raman S. Present developments in polymer microneedle for transdermal drug supply. Int J Pharm. 2020;587:119673.

    Article 

    Google Scholar
     

  • Pawley DC, Goncalves S, Bas E, Dikici E, Deo SK, Daunert S, Telischi F. Dexamethasone (DXM)-coated poly(lactic-co-glycolic acid) (PLGA) microneedles as an improved drug supply system for intracochlear biodegradable gadgets. Adv Ther. 2021;4:2100155.

    Article 
    CAS 

    Google Scholar
     

  • Leong S, Aksit A, Szeto B, Feng SJ, Ji X, Soni RK, Olson ES, Kysar JW, Lalwani AK. Anatomic, physiologic, and proteomic penalties of repeated microneedle-mediated perforations of the spherical window membrane. Hear Res. 2023;432:108739.

    Article 
    PubMed 

    Google Scholar
     

  • Chikar JA, Hendricks JL, Richardson-Burns SM, Raphael Y, Pfingst BE, Martin DC. The usage of a twin PEDOT and RGD-functionalized alginate hydrogel coating to supply sustained drug supply and improved cochlear implant perform. Biomaterials. 2012;33:1982–90.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang Y, Guo J, Cao X, Zhao Y. Growing conductive hydrogels for biomedical functions. Sensible Med. 2024;3:e20230023.

    Article 
    PubMed 

    Google Scholar
     

  • Chen G, Wang F, Zhang X, Shang Y, Zhao Y. Dwelling microecological hydrogels for wound therapeutic. Sci Adv. 2023;9:eadg3478.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Coviello T, Matricardi P, Alhaique F. Drug supply methods utilizing polysaccharidic gels. Knowledgeable Opin Drug Deliv. 2006;3:395–404.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mano JF, Silva GA, Azevedo HS, Malafaya PB, Sousa RA, Silva SS, Boesel LF, Oliveira JM, Santos TC, Marques AP, et al. Pure origin biodegradable techniques in tissue engineering and regenerative medication: current standing and a few transferring developments. J R Soc Interface. 2007;4:999–1030.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Noushi F, Richardson RT, Hardman J, Clark G, O’Leary S. Supply of neurotrophin-3 to the cochlea utilizing alginate beads. Otol Neurotol. 2005;26:528–33.

    Article 
    PubMed 

    Google Scholar
     

  • Endo T, Nakagawa T, Kita T, Iguchi F, Kim TS, Tamura T, Iwai Okay, Tabata Y, Ito J. Novel technique for therapy of internal ears utilizing a biodegradable gel. Laryngoscope. 2005;115:2016–20.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen Okay, Wang F, Ding R, Cai Z, Zou T, Zhang A, Guo D, Ye B, Cui W, Xiang M. Adhesive and injectable hydrogel microspheres for internal ear therapy. Small. 2022;18:e2106591.

    Article 
    PubMed 

    Google Scholar
     

  • Wang J, Wang C, Wang Q, Zhang Z, Wang H, Wang S, Chi Z, Shang L, Wang W, Shu Y. Microfluidic preparation of gelatin methacryloyl microgels as native drug supply automobiles for listening to loss remedy. ACS Appl Mater Interfaces. 2022;14:46212–23.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Feng B, Dong T, Tune X, Zheng X, Jin C, Cheng Z, Liu Y, Zhang W, Wang X, Tao Y, Wu H. Customized porous gelatin methacryloyl sustained-release nicotinamide protects in opposition to noise-induced listening to loss. Adv Sci (Weinh). 2024;11:e2305682.

    Article 
    PubMed 

    Google Scholar
     

  • Chen G, Zhang X, Yang F, Mu L. Disposition of nanoparticle-based supply system by way of internal ear administration. Curr Drug Metab. 2010;11:886–97.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Huang D, Cai L, Li N, Zhao Y. Ultrasound-trigged micro/nanorobots for biomedical functions. Sensible Med. 2023;2:e20230003.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jaudoin C, Agnely F, Nguyen Y, Ferrary E, Bochot A. Nanocarriers for drug supply to the internal ear: physicochemical key parameters, biodistribution, security and efficacy. Int J Pharm. 2021;592:120038.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhao Z, Han Z, Naveena Okay, Lei G, Qiu S, Li X, Li T, Shi X, Zhuang W, Li Y, et al. ROS-responsive nanoparticle as a berberine service for OHC-targeted remedy of noise-induced listening to loss. ACS Appl Mater Interfaces. 2021;13:7102–14.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang Y, Smart AK, Tan J, Maina JW, Shepherd RK, Caruso F. Mesoporous silica supraparticles for sustained inner-ear drug supply. Small. 2014;10:4244–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xu Okay, Du Y, Xu B, Huang Y, Feng W, Yu D, Chen Y, Wang X. Gelatin-encapsulated tetrahedral DNA nanostructure enhances mobile internalization for treating noise-induced listening to loss. Small. 2024;20:e2310604.

  • Gao G, Liu Y, Zhou CH, Jiang P, Solar JJ. Strong lipid nanoparticles loaded with edaravone for internal ear safety after noise publicity. Chin Med J (Engl). 2015;128:203–9.

    Article 
    PubMed 

    Google Scholar
     

  • Martín-Saldaña S, Palao-Suay R, Aguilar MR, García-Fernández L, Arévalo H, Trinidad A, Ramírez-Camacho R. San Román J: pH-sensitive polymeric nanoparticles with antioxidant and anti inflammatory properties in opposition to cisplatin-induced listening to loss. J Management Launch. 2018;270:53–64.

    Article 
    PubMed 

    Google Scholar
     

  • Szeto B, Chiang H, Valentini C, Yu M, Kysar JW, Lalwani AK. Inside ear supply: challenges and alternatives. Laryngoscope Investig Otolaryngol. 2020;5:122–31.

    Article 
    PubMed 

    Google Scholar
     

  • Hao J, Li SK. Inside ear drug supply: current advances, challenges, and perspective. Eur J Pharm Sci. 2019;126:82–92.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • De Ceulaer G, Johnson S, Yperman M, Daemers Okay, Offeciers FE, O’Donoghue GM, Govaerts PJ. Lengthy-term analysis of the impact of intracochlear steroid deposition on electrode impedance in cochlear implant sufferers. Otol Neurotol. 2003;24:769–74.

    Article 
    PubMed 

    Google Scholar
     

  • Prenzler NK, Salcher R, Lenarz T, Gaertner L, Warnecke A. Dose-dependent transient lower of impedances by deep intracochlear injection of triamcinolone with a cochlear catheter previous to cochlear implantation-1 12 months knowledge. Entrance Neurol. 2020;11:258.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Macherey O, Carlyon RP. Cochlear implants. Curr Biol. 2014;24:R878–84.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Duan ML, Ulfendahl M, Laurell G, Counter SA, Pyykkö I, Borg E, Rosenhall U. Safety and therapy of sensorineural listening to problems attributable to exogenous elements: experimental findings and potential medical utility. Hear Res. 2002;169:169–78.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Astolfi L, Guaran V, Marchetti N, Olivetto E, Simoni E, Cavazzini A, Jolly C, Martini A. Cochlear implants and drug supply: in vitro analysis of dexamethasone launch. J Biomed Mater Res B Appl Biomater. 2014;102:267–73.

    Article 
    PubMed 

    Google Scholar
     

  • Mukherjee S, Kuroiwa M, Oakden W, Paul BT, Noman A, Chen J, Lin V, Dimitrijevic A, Stanisz G, Le TN. Native magnetic supply of adeno-associated virus AAV2(quad Y-F)-mediated BDNF gene remedy restores listening to after noise harm. Mol Ther. 2022;30:519–33.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pinyon JL, Tadros SF, Froud KE, AC YW, Tompson IT, Crawford EN, Ko M, Morris R, Klugmann M, Housley GD. Shut-field electroporation gene supply utilizing the cochlear implant electrode array enhances the bionic ear. Sci Transl Med. 2014;6:233ra254.

    Article 

    Google Scholar
     

  • Duan YY, Clark GM, Cowan RS. A research of intra-cochlear electrodes and tissue interface by electrochemical impedance strategies in vivo. Biomaterials. 2004;25:3813–28.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Richardson RT, Smart AK, Thompson BC, Flynn BO, Atkinson PJ, Fretwell NJ, Fallon JB, Wallace GG, Shepherd RK, Clark GM, O’Leary SJ. Polypyrrole-coated electrodes for the supply of cost and neurotrophins to cochlear neurons. Biomaterials. 2009;30:2614–24.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Borre ED, Kaalund Okay, Frisco N, Zhang G, Ayer A, Kelly-Hedrick M, Reed SD, Emmett SD, Francis H, Tucci DL, et al. The affect of listening to loss and its therapy on health-related high quality of life utility: a scientific evaluation with meta-analysis. J Gen Intern Med. 2023;38:456–79.

    Article 
    PubMed 

    Google Scholar
     

  • Yeo BSY, Tune H, Toh EMS, Ng LS, Ho CSH, Ho R, Service provider RA, Tan BKJ, Loh WS. Affiliation of listening to aids and cochlear implants with cognitive decline and dementia: a scientific evaluation and meta-analysis. JAMA Neurol. 2023;80:134–41.

    Article 
    PubMed 

    Google Scholar
     

  • Kim ES, Gustenhoven E, Mescher MJ, Pararas EE, Smith KA, Spencer AJ, Tandon V, Borenstein JT, Fiering J. A microfluidic reciprocating intracochlear drug supply system with reservoir and energetic dose management. Lab Chip. 2014;14:710–21.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen H, Zhao Y, Li J, Guo M, Wan J, Weitz DA, Stone HA. Reactions in double emulsions by flow-controlled coalescence of encapsulated drops. Lab Chip. 2011;11:2312–5.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Guo J, Yu Y, Cai L, Wang Y, Shi Okay, Shang L, Pan J, Zhao Y. Microfluidics for versatile electronics. Mater As we speak. 2021;44:105–35.

    Article 
    CAS 

    Google Scholar
     

  • Shang L, Yu Y, Gao W, Wang Y, Qu L, Zhao Z, Chai R, Zhao Y. Bio-inspired anisotropic wettability surfaces from dynamic ferrofluid assembled templates. Adv Funct Mater. 2018;28:1705802.

    Article 

    Google Scholar
     

  • Ye B, Rong F, Gu H, Xie Z, Cheng Y, Zhao Y, Gu Z. Bioinspired angle-independent photonic crystal colorimetric sensing. Chem Commun (Camb). 2013;49:5331–3.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen Z, Kujawa SG, McKenna MJ, Fiering JO, Mescher MJ, Borenstein JT, Swan EE, Sewell WF. Inside ear drug supply by way of a reciprocating perfusion system within the Guinea pig. J Management Launch. 2005;110:1–19.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tandon V, Kang WS, Robbins TA, Spencer AJ, Kim ES, McKenna MJ, Kujawa SG, Fiering J, Pararas EE, Mescher MJ, et al. Microfabricated reciprocating micropump for intracochlear drug supply with built-in drug/fluid storage and electronically managed dosing. Lab Chip. 2016;16:829–46.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhu Y, Kong B, Liu R, Zhao Y. Growing biomedical engineering applied sciences for reproductive medication. Sensible Med. 2022;1:e20220006.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang H, Chen G, Yu Y, Guo J, Tan Q, Zhao Y. Microfluidic printing of slippery textiles for medical drainage round wounds. Adv Sci (Weinh). 2020;7:2000789.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Creff G, Bernard-Le Liboux N, Coudert P, Bourdon H, Pean V, Wallaert N, Lambert C, Godey B. Tonotopic and default frequency becoming for music notion in cochlear implant recipients: a randomized medical trial. JAMA Otolaryngol Head Neck Surg. 2024;150:960–8.

    Article 
    PubMed 

    Google Scholar
     

  • van Heteren JAA, Wendrich AW, Peters JPM, Grolman W, Stokroos RJ, Smit AL. Speech notion in noise after cochlear implantation for single-sided deafness: a randomized medical trial. JAMA Otolaryngol Head Neck Surg. 2025;151:211–9.

    Article 
    PubMed 

    Google Scholar
     

  • Vogel A, Saborowski A, Wenzel P, Wege H, Folprecht G, Kretzschmar A, Schütt P, Jacobasch L, Ziegenhagen N, Boeck S, et al. Nanoliposomal irinotecan and fluorouracil plus leucovorin versus fluorouracil plus leucovorin in sufferers with cholangiocarcinoma and gallbladder carcinoma beforehand handled with gemcitabine-based therapies (AIO NALIRICC): a multicentre, open-label, randomised, part 2 trial. Lancet Gastroenterol Hepatol. 2024;9:734–44.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Related Articles

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    [td_block_social_counter facebook="tagdiv" twitter="tagdivofficial" youtube="tagdiv" style="style8 td-social-boxed td-social-font-icons" tdc_css="eyJhbGwiOnsibWFyZ2luLWJvdHRvbSI6IjM4IiwiZGlzcGxheSI6IiJ9LCJwb3J0cmFpdCI6eyJtYXJnaW4tYm90dG9tIjoiMzAiLCJkaXNwbGF5IjoiIn0sInBvcnRyYWl0X21heF93aWR0aCI6MTAxOCwicG9ydHJhaXRfbWluX3dpZHRoIjo3Njh9" custom_title="Stay Connected" block_template_id="td_block_template_8" f_header_font_family="712" f_header_font_transform="uppercase" f_header_font_weight="500" f_header_font_size="17" border_color="#dd3333"]
    - Advertisement -spot_img

    Latest Articles