Aletaha, D. & Smolen, J. S. Analysis and administration of rheumatoid arthritis: a evaluation. JAMA 320, 1360–1372 (2018).
Gravallese, E. M. & Firestein, G. S. Rheumatoid arthritis—widespread origins, divergent mechanisms. N. Engl. J. Med. 388, 529–542 (2023).
Zhang, F. et al. Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature 623, 616–624 (2023).
Fearon, U., Hanlon, M. M., Floudas, A. & Veale, D. J. Mobile metabolic variations in rheumatoid arthritis and their therapeutic implications. Nat. Rev. Rheumatol. 18, 398–414 (2022).
Buckley, C. D., Ospelt, C., Homosexual, S. & Midwood, Okay. S. Location, location, location: how the tissue microenvironment impacts irritation in RA. Nat. Rev. Rheumatol. 17, 195–212 (2021).
Weyand, C. M. & Goronzy, J. J. Immunometabolism in early and late phases of rheumatoid arthritis. Nat. Rev. Rheumatol. 13, 291–301 (2017).
Boutet, M. A. et al. Novel insights into macrophage variety in rheumatoid arthritis synovium. Autoimmun. Rev. 20, 102758 (2021).
Martel-Pelletier, J. et al. Osteoarthritis. Nat. Rev. Dis. Prim. 2, 16072 (2016).
Burmester, G. R. & Pope, J. E. Novel therapy methods in rheumatoid arthritis. Lancet 389, 2338–2348 (2017).
Nissen, S. E. et al. Cardiovascular security of celecoxib, naproxen, or ibuprofen for arthritis. N. Engl. J. Med. 375, 2519–2529 (2016).
Erhardt, D. P. et al. Low persistence charges in sufferers with rheumatoid arthritis handled with triple remedy and antagonistic drug occasions related to sulfasalazine. Arthritis Care Res. 71, 1326–1335 (2019).
Zhu, Y. et al. Rheumatoid arthritis microenvironment insights into therapy impact of nanomaterials. Nano At the moment 42, 101358 (2022).
Nizet, V. & Johnson, R. S. Interdependence of hypoxic and innate immune responses. Nat. Rev. Immunol. 9, 609–617 (2009).
Zhao, Y. et al. Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis remedy. Nat. Commun. 13, 6758 (2022).
Zhang, Q. et al. Neutrophil membrane-coated nanoparticles inhibit synovial irritation and alleviate joint injury in inflammatory arthritis. Nat. Nanotechnol. 13, 1182–1190 (2018).
Jia, M. et al. Messenger nanozyme for reprogramming the microenvironment of rheumatoid arthritis. ACS Appl. Mater. Interfaces 15, 338–353 (2023).
Kim, J. et al. Synergistic oxygen technology and reactive oxygen species scavenging by manganese ferrite/ceria co-decorated nanoparticles for rheumatoid arthritis therapy. ACS Nano 13, 3206–3217 (2019).
Yang, Y. et al. Focused silver nanoparticles for rheumatoid arthritis remedy through macrophage apoptosis and re-polarization. Biomaterials 264, 120390 (2021).
Yang, J., Yang, B. & Shi, J. A nanomedicine-enabled ion-exchange technique for enhancing curcumin-based rheumatoid arthritis remedy. Angew. Chem. Int. Ed. 62, e202310061 (2023).
Xu, C. et al. Arthritic microenvironment actuated nanomotors for energetic rheumatoid arthritis remedy. Adv. Sci. 10, e2204881 (2023).
Chen, J. et al. Photoacoustic image-guided biomimetic nanoparticles focusing on rheumatoid arthritis. Proc. Natl Acad. Sci. USA 119, e2213373119 (2022).
Koo, S. et al. Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis mannequin. Nat. Nanotechnol. 18, 1502–1514 (2023).
Del Giudice, G. et al. An ancestral molecular response to nanomaterial particulates. Nat. Nanotechnol. 18, 957–966 (2023).
Stater, E. P., Sonay, A. Y., Hart, C. & Grimm, J. The ancillary results of nanoparticles and their implications for nanomedicine. Nat. Nanotechnol. 16, 1180–1194 (2021).
Gao, J. et al. Intracerebral destiny of natural and inorganic nanoparticles relies on microglial extracellular vesicle perform. Nat. Nanotechnol. 19, 376–386 (2024).
Li, Y. et al. Innate immunity-modulating nanobiomaterials for controlling irritation decision. Matter 7, 3811–3844 (2024).
Zhang, M. et al. Edible ginger-derived nanoparticles: a novel therapeutic strategy for the prevention and therapy of inflammatory bowel illness and colitis-associated most cancers. Biomaterials 101, 321–340 (2016).
Chen, Q. et al. Pure exosome-like nanovesicles from edible tea flowers suppress metastatic breast most cancers through ROS technology and microbiota modulation. Acta Pharm. Sin. B 12, 907–923 (2022).
Feng, T., Ahmed, W., Ahmed, T. & Chen, L. Nanoparticles derived from natural preparations might symbolize a novel nucleic acid remedy. Interdiscip. Med. 2, e20230029 (2024).
Miller, T. E. et al. Mild-powered CO2 fixation in a chloroplast mimic with pure and artificial elements. Science 368, 649–654 (2020).
Gao, F. et al. Synthetic photosynthetic cells with biotic–abiotic hybrid vitality modules for custom-made CO2 conversion. Nat. Commun. 14, 6783 (2023).
Hou, L. et al. Hybrid-membrane-decorated Prussian blue for efficient most cancers immunotherapy through tumor-associated macrophages polarization and hypoxia aid. Adv. Mater. 34, e2200389 (2022).
Suk, J. S., Xu, Q., Kim, N., Hanes, J. & Ensign, L. M. PEGylation as a technique for enhancing nanoparticle-based drug and gene supply. Adv. Drug Deliv. Rev. 99, 28–51 (2016).
Kobayashi, Okay., Jimbo, H., Nakamura, Y. & Wada, H. Biosynthesis of phosphatidylglycerol in photosynthetic organisms. Prog. Lipid Res. 93, 101266 (2024).
Pali, T., Garab, G., Horvath, L. I. & Kota, Z. Useful significance of the lipid-protein interface in photosynthetic membranes. Cell. Mol. Life Sci. 60, 1591–1606 (2003).
Liu, J. et al. Supply of biomimetic liposomes through meningeal lymphatic vessels route for focused remedy of Parkinson’s illness. Analysis 6, 0030 (2023).
Hao, M. et al. Mixture of metabolic intervention and T cell remedy enhances strong tumor immunotherapy. Sci. Transl. Med. 12, eaaz6667 (2020).
Barber, J. A mechanism for water splitting and oxygen manufacturing in photosynthesis. Nat. Vegetation 3, 17041 (2017).
Kafri, M. et al. Systematic identification and characterization of genes within the regulation and biogenesis of photosynthetic equipment. Cell 186, 5638–5655.25 (2023).
Hald Albertsen, C. et al. The position of lipid elements in lipid nanoparticles for vaccines and gene remedy. Adv. Drug Deliv. Rev. 188, 114416 (2022).
Chen, P. et al. A plant-derived pure photosynthetic system for enhancing cell anabolism. Nature 612, 546–554 (2022).
Alivernini, S. et al. Distinct synovial tissue macrophage subsets regulate irritation and remission in rheumatoid arthritis. Nat. Med. 26, 1295–1306 (2020).
Smolen, J. S. et al. Rheumatoid arthritis. Nat. Rev. Dis. Prim. 4, 18001 (2018).
Lan, R. et al. Folate receptor-targeted NIR-II dual-model nanoprobes for multiscale visualization of macrophages in rheumatoid arthritis. Adv. Func. Mat. 33, 2300342 (2023).
Ma, Y. et al. DNA origami as a nanomedicine for focused rheumatoid arthritis remedy via reactive oxygen species and nitric oxide scavenging. ACS Nano 16, 12520–12531 (2022).
Hegarty, L. M., Jones, G. R. & Bain, C. C. Macrophages in intestinal homeostasis and inflammatory bowel illness. Nat. Rev. Gastroenterol. Hepatol. 20, 538–553 (2023).
Venkatesan, R. et al. Immuno-modulating theranostic gold nanocages for the therapy of rheumatoid arthritis in vivo. Chem. Eng. J. 446, 136868 (2022).
Tardito, S. et al. Macrophage M1/M2 polarization and rheumatoid arthritis: a scientific evaluation. Autoimmun. Rev. 18, 102397 (2019).
Liu, Y. et al. Multifunctional Janus nanoplatform for effectively synergistic theranostics of rheumatoid arthritis. ACS Nano 17, 8167–8182 (2023).
You, D. G. et al. Metabolically engineered stem cell–derived exosomes to control macrophage heterogeneity in rheumatoid arthritis. Sci. Adv. 7, eabe0083 (2021).
Rodriguez-Ramiro, I. et al. Pharmacological and genetic will increase in liver NADPH ranges ameliorate NASH development in feminine mice. Free Radic. Biol. Med. 210, 448–461 (2024).
Weng, L. et al. Surplus fatty acid synthesis will increase oxidative stress in adipocytes and lnduces lipodystrophy. Nat. Commun. 15, 133 (2024).
Fearon, U., Canavan, M., Biniecka, M. & Veale, D. J. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat. Rev. Rheumatol. 12, 385–397 (2016).
Jia, N. et al. Metabolic reprogramming of proinflammatory macrophages by goal delivered roburic acid successfully ameliorates rheumatoid arthritis signs. Sign Transduct. Goal Ther. 8, 280 (2023).
Guan, F. et al. Tissue macrophages: origin, heterogenity, organic capabilities, illnesses and therapeutic targets. Sign Transduct. Goal Ther. 10, 93 (2025).
Wang, Z. et al. A focused exosome therapeutic confers each CfDNA scavenging and macrophage polarization for ameliorating rheumatoid arthritis. Adv. Mater. 35, e2302503 (2023).
Li, L. et al. M2 macrophage-derived sEV regulate pro-inflammatory CCR2+ macrophage subpopulations to favor post-AMI cardiac restore. Adv. Sci. 10, e2202964 (2023).
Qiao, Y. et al. Engineered algae: a novel oxygen-generating system for efficient therapy of hypoxic most cancers. Sci. Adv. 6, eaba5996 (2020).
Wang, W. et al. Engineering micro oxygen factories to sluggish tumour development through hyperoxic microenvironments. Nat. Commun. 13, 4495 (2022).
Zhong, D. et al. Microalgae-based hydrogel for inflammatory bowel illness and its related nervousness and despair. Adv. Mater. 36, e2312275 (2024).
Ouyang, J. et al. Biomimetic nanothylakoids for environment friendly imaging-guided photodynamic remedy for most cancers. Chem. Commun. 54, 3468–3471 (2018).
Chen, B., Ni, Y., Liu, J., Zhang, Y. & Yan, F. Bone marrow-derived mesenchymal stem cells exert various results on totally different macrophage subsets. Stem Cells Int. 2018, 8348121 (2018).
Wynn, T. A., Chawla, A. & Pollard, J. W. Macrophage biology in improvement, homeostasis and illness. Nature 496, 445–455 (2013).
Ma, C. et al. Considerably enhancing the bioefficacy for rheumatoid arthritis with supramolecular nanoformulations. Adv. Mater. 33, e2100098 (2021).
