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Saturday, August 1, 2026

The Obtain: Montana’s new experimental drug guidelines


That is as we speak’s version of The Obtain, our weekday e-newsletter that gives a every day dose of what’s occurring on the earth of expertise.

Montana’s plan to grow to be an experimental medical hub simply pushed ahead 

As of this week in Montana, biotech firms whose medicine have been by preliminary testing—generally in as few as 10 wholesome folks—will pay $12,500 to use to a newly established evaluation board for approval.

As soon as its therapy is rubber-stamped, the corporate can promote it through experimental therapy clinics, the primary of which is prone to be up and operating across the finish of this yr.   

Montana’s newest right-to-try laws is exclusive. Entry to medicine is theoretically accessible to anybody who offers knowledgeable consent and will pay. For some, particularly folks within the longevity neighborhood, that’s a hopeful and thrilling prospect. However to others, it’s unethical and harmful. 

Learn our story to study the place this may occasionally all be headed. 

—Jessica Hamzelou

Montana’s new “proper to attempt” regulation can’t come quickly sufficient for some 

Kris DeVault is determined.

His son, Brody, born in March 2023, has one thing referred to as creatine transporter deficiency—a uncommon situation by which the mind and muscular tissues lack the vitality they should develop.

There aren’t any cures for Brody’s situation. However DeVault has discovered of an organization growing a drug that may assist. That drug continues to be within the early phases of improvement and has solely been examined in animals and a small variety of wholesome adults. Medical doctors can’t prescribe it.

DeVault is aware of the drug may not work. However he’s doing all he can to entry it regardless. Learn our story about DeVault’s efforts. 

—Jessica Hamzelou

This story is from The Checkup, our weekly biotech e-newsletter. Enroll to obtain it in your inbox each Thursday.

The must-reads

I’ve combed the web to search out you as we speak’s most enjoyable/vital/scary/fascinating tales about expertise.

1 Anthropic says its fashions hacked exterior organisations throughout testing
It was prompted to conduct a evaluation after comparable points at OpenAI. (TechCrunch
+ Inside OpenAI’s hack of Hugging Face. (New Yorker $)
+ OpenAI referred to as the Hugging Face assault unprecedented. However we’ve been right here earlier than. (MIT Know-how Overview)

2 Europe is bracing itself for an much more fiery future
Nations like France and Spain can count on regimes akin to these in California. (Nature $)
+ Even the UK is experiencing fires now, too. (Guardian)
+ El Niño is partly accountable for this yr’s grueling heatwaves. (Wired $)
+ District cooling might assist beat excessive warmth in cities. (New Scientist $)

3 Drone warfare is making the skies extra harmful
A deadly aircraft accident within the US this Could, brought on by a navy GPS jamming train, might sign what’s to come back. (Wired$)
+ Zelensky requested Trump to safe Musk’s permission for using Starlink to information drone strikes inside Russia this week. (The Atlantic $)

4 As Massive Tech’s AI spending grows, so do the jitters
Amazon, Google, Meta and Microsoft are set to take a position $1.5 trillion into AI infrastructure. However who pays for it? (NYT $)
Are traders actually getting chilly ft concerning the AI growth? (FT $)
An AI-focused hedge fund simply imploded. (CNBC)

5 How China has modified the sovereign AI playbook
Kimi 3 from Moonshot makes forking out for costly US fashions appear silly. (Remainder of World)
+ The US is profitable on the leading edge. However China dominates low-cost fashions. (CNBC)
May AI find yourself too low-cost to manage? (Vox $)

6 Google’s Gemini can now management a humanoid robotic
It was beforehand restricted to higher physique actions. Now, it may handle your entire vary of movement. (Bloomberg $)
These gig employees are coaching humanoid robots at residence. (MIT Know-how Overview)

7 Amazon says it’s discovered “catastrophically costly” AI value overruns
It’s removed from alone—and that’s why the “tokenmaxxing” development disappeared so rapidly. (FT $)

8 How a distant indigenous neighborhood constructed a brilliant quick fiber community
It was a fancy, costly endeavor. However it now outperforms Starlink. (IEEE Spectrum
Stratospheric web might lastly begin taking off this yr. (MIT Know-how Overview)

9 Meet Wikipedia’s most diligent editor
Steven Pruitt is unremarkable in some methods—but actually superb in others. (New Yorker $)

10 Now you can report AI slop with a button on LinkedIn
The folks have spoken. And they’re uninterested in studying bland nonsense. (404 Media)

Quote of the day

“It’s a shock, pondering that simply an hour earlier I’d been in my room and every little thing… and now, there’s nothing left.”

—18-year-old Raphael Fohanno tells Reuters his response to wildfires destroying his dad and mom’ home within the French city of Biscarrosse.

One Extra Factor

""
A few of the 750 experiences printed by the OTA throughout its 23-year historical past.
GOVERNMENT PRINTING OFFICE VIA PRINCETON UNIVERSITY

Congress used to judge rising applied sciences. Let’s do it once more.

The US Workplace of Know-how Evaluation, an unbiased workplace created by Congress within the early Seventies, produced some 750 experiences throughout its 23-year historical past, assessing applied sciences as diversified as digital surveillance, genetic engineering, and distant sensing from outer area. 

The workplace functioned like a debunking arm. It sussed out the snake oil. Its experiences noticed by the alluring gleam of overhyped applied sciences. 

Since its unceremonious defunding in 1995, perennial calls have gone out: Rouse the workplace from the useless! 

Learn our story about why, with advances in robotics, huge information, and AI methods, these calls have taken on a brand new degree of urgency. 

—Peter Andrey Smith

We are able to nonetheless have good issues

A spot for consolation, enjoyable, and distraction to brighten up your day. (Received any concepts? Drop me a line.)

Fencing on curler skates is the self-defense you didn’t know you wanted.
+  Meet Pumpkin, a chubby cat that’s in no temper to shed weight.
+ Uncover what the animals close to you’re in all probability doing proper now at Nature This Week.
+ Woodworker extraordinaire Matt Thompson has put in a mannequin railroad that runs alongside his fence



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