Investigating chiral light-matter interactions is important for advancing purposes in sensing, imaging, and pharmaceutical growth. Nevertheless, the chiroptical response in pure chiral molecules and subwavelength chiral constructions is inherently weak, with the traditional characterization instruments restricted to optical strategies that make the most of circularly polarized gentle. To beat this, optical vortex beams, characterised by helical wavefronts, have emerged as a compelling analysis focus. Helical dichroism (HD) represents the differential absorbance of vortex beams with reverse indicators of topological expenses. Through the use of inverse design for topology optimization, we design the chiral construction for enhanced HD response underneath OAM beam incidence, demonstrating an enormous HD response of ∼107% with topological expenses |±
| = 3 on the wavelength of 800 nm. This research reveals distinct helicity-dependent interactions between the chiral construction and OAM beams, highlighting the potential for extremely delicate chiral units.
