These days, intracellular bacterial an infection attributable to antibiotic-resistant pathogens, akin to methicillin-resistant Staphylococcus aureus (MRSA), poses an intractable menace to public well being. Intracellular MRSA is extraordinarily tough to eradicate by conventional antibiotics as a result of poor intracellular accumulation and drug resistance. On this work, a novel multifunctional nanoantibiotic (GZNC) was constructed by MOF-derived nanozymes loaded with botanicals for synergistic therapy of intracellular antibiotic-resistant bacterial an infection. The nanoantibiotic built-in glycyrrhizinic acid (GA) into ZIF-8-derived nanozymes (ZNC), which achieved a managed launch of GA, glorious photothermal results and enhanced peroxidase-like (POD-like) exercise below the near-infrared (NIR) gentle irradiation. The nanoantibiotic confirmed the superb potential for in vivo and in vitro eradication of intracellular antibiotic-resistant micro organism. With the deserves of NIR light-actuated botanicals/photothermal remedy (PTT)/chemodynamic remedy (CDT), the nanoantibiotic may synergistically eradicate intracellular antibiotic-resistant micro organism and alleviate related an infection, offering a promising and biologically protected pathway to handle the intracellular antibiotic-resistant bacterial an infection.
